Can some one please help me with this hi jack this lod and tell me if any thing looks bad?

Logfile of Trend Micro HijackThis v2.0.4
Scan saved at 5:50:02 AM, on 6/8/2010
Platform: Windows Vista (WinNT 6.00.1904)
MSIE: Internet Explorer v7.00 (7.00.6000.17037)
Boot mode: Normal

Running processes:
C:\Windows\system32\taskeng.exe
C:\Windows\system32\Dwm.exe
C:\Program Files\TuneUp Utilities 2010\TuneUpUtilitiesApp32.exe
C:\Windows\Explorer.EXE
C:\Program Files\Alwil Software\Avast5\AvastUI.exe
C:\Windows\System32\wpcumi.exe
C:\Windows\system32\wuauclt.exe
C:\Windows\system32\SearchFilterHost.exe
C:\Program Files\Trend Micro\HiJackThis\HiJackThis.exe

R1 – HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 – HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R1 – HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 – HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 – HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 – HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R0 – HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant =
R0 – HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch =
R0 – HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
O1 – Hosts: ::1 localhost
O3 – Toolbar: MSN Toolbar – {8dcb7100-df86-4384-8842-8fa844297b3f} – C:\Program Files\MSN Toolbar\Platform.0.0360.0\npwinext.dll
O3 – Toolbar: (no name) – {9D425283-D487-4337-BAB6-AB8354A81457} – (no file)
O4 – HKLM\..\Run: [Windows Defender] %ProgramFiles%\Windows Defender\MSASCui.exe -hide
O4 – HKLM\..\Run: [avast5] C:\PROGRA~1\ALWILS~1\Avast5\avastUI.exe /nogui
O4 – HKLM\..\Run: [WPCUMI] C:\Windows\system32\WpcUmi.exe
O4 – HKLM\..\Run: [QuickTime Task] “C:\Program Files\QuickTime\QTTask.exe” -atboottime
O4 – HKUS\S-1-5-19\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User ‘LOCAL SERVICE’)
O4 – HKUS\S-1-5-19\..\Run: [WindowsWelcomeCenter] rundll32.exe oobefldr.dll,ShowWelcomeCenter (User ‘LOCAL SERVICE’)
O4 – HKUS\S-1-5-20\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User ‘NETWORK SERVICE’)
O16 – DPF: {D27CDB6E-AE6D-11CF-96B8-444553540000} (Shockwave Flash Object) – http://fpdownload2.macromedia.com/get/shockwave/cabs/flash/swflash.cab
O22 – SharedTaskScheduler: Component Categories cache daemon – {8C7461EF-2B13-11d2-BE35-3078302C2030} – C:\Windows\system32\browseui.dll
O22 – SharedTaskScheduler: har98fefiesjfs93s8i9sejsdf – {C7BA40A1-74F2-52BD-F411-04B15A2C8953} – (no file)
O23 – Service: avast! Antivirus – ALWIL Software – C:\Program Files\Alwil Software\Avast5\AvastSvc.exe
O23 – Service: avast! Mail Scanner – ALWIL Software – C:\Program Files\Alwil Software\Avast5\AvastSvc.exe
O23 – Service: avast! Web Scanner – ALWIL Software – C:\Program Files\Alwil Software\Avast5\AvastSvc.exe
O23 – Service: @C:\Program Files\TuneUp Utilities 2010\TuneUpDefragService.exe,-1 (TuneUp.Defrag) – TuneUp Software – C:\Program Files\TuneUp Utilities 2010\TuneUpDefragService.exe
O23 – Service: TuneUp Utilities Service (TuneUp.UtilitiesSvc) – TuneUp Software – C:\Program Files\TuneUp Utilities 2010\TuneUpUtilitiesService32.exe
O23 – Service: Yahoo! Updater (YahooAUService) – Yahoo! Inc. – C:\Program Files\Yahoo!\SoftwareUpdate\YahooAUService.exe

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End of file – 3584 bytes
well because my system just seems to run a little slow all of a sudden